She will return to the UK for a week’s work in her constituency and in Downing Street before attending the centenary commemoration of the World War One battle of Amiens and then resuming her break in Switzerland.
Mrs May’s trip is a repeat of her holiday itinerary from last year.
The Parliamentary recess plans of her Conservative colleagues have also been split on Europe – Brexiteers have largely chosen to holiday in the UK or US, while Remainers select countries in the EU.
Image copyrightEPAImage caption Mrs May and her husband Philip arrived by boat in Sirmione, on Lake Garda in Italy, on Saturday
Jacob Rees-Mogg, chairman of the Tories’ pro-Brexit European Research Group, is holidaying in the US, as is International Trade Secretary Liam Fox, after a detour in Japan.
Environment Secretary Michael Gove, who led the Vote Leave campaign, will be taking a break in Scotland.
The office of staunch Remainer Anna Soubry, meanwhile, said she would be taking a holiday in Europe.
Mrs May has long favoured visiting Switzerland – not in the EU – and the Alps because of her enthusiasm for hiking.
She has previously praised the region for its views and clear air.
Image copyrightPAImage caption It is the second year running that Mrs May and her husband have visited the lakeside township of Desenzano del Garda